Photo by Caroline Nunez

Hotels in Mayesville

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Where to stay in Mayesville?

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Mayesville

The region around Mayesville is home to attractions such as Crystal Lakes Golf Course and O'Donnell House.

Somewhere in rural South Carolina off a back road to my hometown. Saw the sunflower field and had to stop.
Photo by Caroline Nunez
Open Photo by Caroline Nunez

Frequently asked questions

What hotels do travelers like in Mayesville?
Can I book a refundable accommodation in Mayesville?
If you need the flexibility to change your travel plans to Mayesville, most hotels offer refundable* bookable rates. You can find these properties by searching our site and using the “fully refundable” filter to narrow the results down.
What will the weather in Mayesville be like during my vacation?
July and August are typically the warmest months in Mayesville when the average temp is 79°F. January and February are the coldest months when the average temperature is 50°F. August and July are the months with the most rain.
Why should I book my Mayesville hotel through Hotels.com?
There are lots of reasons to book your Mayesville trip with us: our free cancellations on selected hotels* gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

Find out more about Mayesville

Find out more about Mayesville

Discover Mayesville: Where Serene Shores Meet Vibrant Adventures

Nestled in the heart of South Carolina, Mayesville is a charming small town that offers a delightful escape into history and nature. With a population of just over 1,000, this quaint destination features a picturesque historic district that invites exploration. Stroll through the scenic parks or enjoy leisurely days by nearby lakes. For those craving a bit more excitement, Myrtle Beach is just a drive away. Mayesville's friendly atmosphere and rich heritage make it a perfect spot for travelers seeking a peaceful retreat, cultural experiences, and a taste of Southern hospitality. For the best hotel rates in Mayesville and to enhance your stay, be sure to check out Hotels.com's Last-Minute DealsOpens in a new window on travel.

Top locations to stay in Mayesville

Some of the best places to stay in Mayesville are Florence, Sumter and Camden. Florence, Sumter, and Camden each offer unique attractions for travelers. Florence is known for its vibrant arts scene and shopping options. Sumter features beautiful parks and historic sites, while Camden boasts rich Revolutionary War history and equestrian events. Accommodation in these areas ranges from cozy inns to modern hotels, providing comfort for all budgets. For first-time visitors, Florence is the best choice due to its diverse activities and amenities, making it an ideal base for exploration. Here are some of our travelers' favorite hotels in Mayesville:

  1. FlorenceOpens in a new window: Florence is a vibrant city with a family-friendly atmosphere and offers a mix of entertainment and shopping experiences. The Florence Civic Center hosts various events and shows, while Magnolia Mall provides ample shopping options. For accommodations, consider TownePlace Suites by Marriott FlorenceOpens in a new window, a 3.5-star hotel that caters to business travelers and pet owners, featuring meeting rooms and a 24-hour business center. Another option is Rosewood Manor House B&BOpens in a new window, a 4.0-star bed and breakfast ideal for business travelers, providing multiple meeting rooms. Lastly, Staybridge Suites Florence - Civic Center, an IHG HotelOpens in a new window, a 3.0-star hotel, also supports business needs and pet stays, offering essential amenities for a comfortable stay.
  2. SumterOpens in a new window: Sumter is known for its beautiful outdoor spaces and recreational activities, making it a perfect destination for family adventures. Swan Lake Iris Gardens is a must-visit botanical garden, alongside the Sumter Mall for shopping. For lodging, consider Affordable Suites Sumter SCOpens in a new window, a 2.5-star hotel with entertainment options like cable TV. 1912 Bed and BreakfastOpens in a new window, a 3.5-star bed and breakfast, is perfect for business travelers and pet owners, featuring a dog exercise area. Hyatt Place Sumter / DowntownOpens in a new window, a 3.0-star hotel, offers business amenities and a pet-friendly environment, ensuring comfort during your stay.
  3. CamdenOpens in a new window: Camden is steeped in history and offers a unique blend of outdoor activities and cultural experiences, highlighted by the Historic Camden Revolutionary War Site. Visitors can enjoy the natural beauty of Woodward Park. For accommodations, The 1425 InnOpens in a new window, a 3.5-star bed and breakfast, is perfect for adventure seekers, offering activities like ziplining and hiking. Graduate by Hilton Columbia SCOpens in a new window, a 4.0-star hotel, caters to business travelers and pet owners, featuring conference spaces. Lastly, Marriott ColumbiaOpens in a new window, a 3.5-star hotel, provides family-friendly amenities and business facilities, making it a great choice for various travelers.

Things to do in Mayesville for first time

Mayesville is an ideal destination for a three-day getaway, offering a beautiful blend of sandy beaches, serene lakes, and lush parks. Visitors can enjoy activities like boating, hiking, and exploring scenic boardwalks, along with vibrant shopping areas to unwind after a day of adventure. Here's a quick itinerary to make the most of your trip to Mayesville:

  • Day 1: Start your exploration in Mayesville with a visit to the Swan Lake Iris Gardens, where you can stroll through beautiful gardens adorned with vibrant irises and peaceful lakes. After soaking in the natural beauty, head over to the O'Donnell House, a historic site that offers a glimpse into the region's past with its charming architecture. Conclude your day at the Sumter County Gallery of Art, where you can appreciate local and regional artworks that reflect the culture and creativity of the area.
  • Day 2: Begin your day at Palmetto Park, a great spot for a leisurely walk or a picnic amidst lush greenery. Next, make your way to Bill Pinkney Park, where you can enjoy recreational activities or simply relax by the water. In the afternoon, visit the Borough House Plantation, a historic plantation that provides insights into the history of the area, along with beautiful views of the surrounding landscape.
  • Day 3: Kick off your day at Lee State Park, where you can immerse yourself in nature with hiking trails and wildlife observation opportunities. Following your outdoor adventure, visit Fryar's Topiary Garden, an enchanting space filled with intricate topiary art that is sure to fascinate. Finally, wrap up your journey at Kalmia Gardens, a hidden gem featuring a diverse array of plants and picturesque walking paths, perfect for reflection and relaxation.

5 tips to find a great Mayesville hotel deal

  1. Book for the cheapest times: The most affordable time to visit Mayesville is from October to December, when hotel prices drop significantly. For a budget-friendly getaway, a stay of at least 1-2 days is recommended to fully enjoy the primary attractions, which include the beach, lake, and park. This makes Mayesville a great value for money destination, perfect for those looking to explore on a budget.
  2. Look for last-minute deals on Hotels.com: If you’re looking for last-minute deals to Mayesville, consider checking out the DealsOpens in a new window or Last-Minute DealsOpens in a new window section on Hotels.com. Here, you may discover discounted hotel rates that suit your travel needs. Additionally, activating email alerts or push notifications from Hotels.com can keep you informed about flash sales and special promotions, helping you seize opportunities to save on your stay.
  3. Be flexible with dates: Hotel prices may fluctuate due to factors like location, star rating, and the time of year. Consequently, if you remain flexible with your travel dates, you could save on hotel expenses in Mayesville.
  4. Consider your location: When booking on Hotels.com for your holiday, take your location into account. Staying closer to major attractions or city centers can offer convenience, but it usually tends to come with a higher price tag. For more affordable options, consider hotels in neighborhoods that are less central, while finding a balance between cost and easy access to the sites you want to visit.
  5. Upgrade with One Key: Book your hotel in Mayesville and join Hotels.com's free One Key rewards program, enabling members to earn and enjoy reward points for hotel reservations. Progress through Blue, Silver, Gold and Platinum tiers and access perks such as room upgrades when available, exclusive discounts, and unique member offers. Join today.

Best time to go to Mayesville

Mayesville experiences its lowest average temperature in January, at 45.9°F (7.7°C), while July is the hottest month, with an average temperature of 81.3°F (27.4°C). August is typically the wettest month. If you’re looking to soak up the lively atmosphere in Mayesville, March, June, and July are the peak months to visit, bustling with fellow travelers. During this peak period, the weather is mostly sunny, accompanied by light rainfall. However, if you prefer a more relaxed experience, January, September, and October are perfect for a quieter getaway, marked by light rainfall and mostly sunny conditions.

If you're looking to discover somewhere new, look no further than Mayesville. Whether you're planning to stay for a night or for the week, the area around Mayesville has accommodations to fit every need. Search for hotels in Mayesville with Hotels.com by checking our online map. Our map displays the areas and neighborhoods around all Mayesville hotels so you can see how close you are from landmarks and attractions, and then refine your search within the larger area. The best Mayesville hotel deals are here with our lowest price guarantee.