Hotels in South Carolina Lowcountry

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Where to stay in South Carolina Lowcountry?

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Great weekend hotel deals in South Carolina Lowcountry, SC

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Check out hotels with an ocean view in South Carolina Lowcountry

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You can also stay at pet-friendly hotels in South Carolina Lowcountry

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top landmarks in Southeastern United States

Learn more about South Carolina Lowcountry

South Carolina Lowcountry is applauded for its cultural attractions such as Penn Center and Parris Island Museum.

Hilton Head featuring heritage architecture
Photo by Hilton Head Island Visitor & Convention Bureau
Open Photo by Hilton Head Island Visitor & Convention Bureau

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Why should I book my South Carolina Lowcountry accommodation with Hotels.com?
There are lots of reasons to book your South Carolina Lowcountry trip with us: our free cancellations on selected hotels gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

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